Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler
نویسندگان
چکیده
The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.
منابع مشابه
Novel nano cellulosic fibers for remediation of heavy metals from synthetic water
The increased surface area-to-volume ratio of nanoparticles, quantum size effects and the ability to tune surface properties through molecular modification make nanostructures ideal for environmental remediation. The present piece of work reports the preparation and characterization of nano cellulosic fibers (NCFs) with further polymeric reinforcement using vinyl sulphonic acid for the remediat...
متن کاملNovel nano cellulosic fibers for remediation of heavy metals from synthetic water
The increased surface area-to-volume ratio of nanoparticles, quantum size effects and the ability to tune surface properties through molecular modification make nanostructures ideal for environmental remediation. The present piece of work reports the preparation and characterization of nano cellulosic fibers (NCFs) with further polymeric reinforcement using vinyl sulphonic acid for the remediat...
متن کاملA Review on Commonly Used Scaffolds in Tissue Engineering for Bone Tissue Regeneration
Introduction: Bone is one of the tissues that have a true potential for regeneration. However, sometimes the bone defects are so outsized that there is no chance of bone self-repair and restoration or the damage is such that it is not possible to repair with medical or surgical interventions. In these situations, bone grafts are the treatment of choice, but due to several obstacles, including l...
متن کاملComparison of liposomal formulations incorporating BMP-2 peptide to induce bone tissue engineering
Objective(s): Fabricating a biomimetic scaffold platform combined with controlled release of bioactive agents is a practical approach for bone tissue engineering. Controlled delivery of peptides and growth factors which play a significant role in osteogenesis is an important issue reducing the associated adverse effects and leading to cost-effectiveness. Materials and Methods: We develope...
متن کاملThe Effects of Dietary Valine on Performance, SerumAntibody Titre and Bone Mineralization in Broiler Chicks
The present study was carried out to examine the effect of supplemental dietary valine in the starter diet of broilers (0-15 d of age) on performance, antibodyresponse to Newcastle disease virus vaccination and bone mineralization. The experiment was conducted using 300 Ross 308 male broilers. One-day-old chicks were randomly allotted to 3 groups; each group consisted of 5 replicate pens with 2...
متن کامل